Derry is crossed by five New Hampshire state highways and one Interstate Highway.

 

NH 28 enters from the south, and follows Rockingham Road north to the southern border of the town's major commercial center.

 

The NH 28 Bypass, known locally as "The Bypass," begins at South Main Street, where NH 28 intersects with Rockingham Road, and continues on South Main Street, North Main Street, and Londonderry Turnpike until traversing the extreme northwestern part of town and into Auburn.

 

NH 102 enters in the west from Londonderry, where it is known as Broadway.

 

NH 111 runs across the town's extreme southeast corner, arriving from Salem in the south and going into Atkinson in the east.

 

NH 121 runs through the most northeastern end of town for a few hundred feet between Hampstead and Sandown.

 

Interstate 93 runs through Derry's southwest corner for less than a mile. The town has no interchanges, however, the interchange with NH 102 in Londonderry is less than 1,000 feet away.

 

The nearest air transport is Manchester–Boston Regional Airport. There is currently no passenger rail service in Derry. Amtrak offers Downeaster service, and the MBTA's Haverhill Line stops 32 miles to the southeast at Haverhill station.